As a pioneer organization on Comprehensive Sexuality Education, Adolescent Sexual and Reproductive Health, Adolescent Friendly Service Delivery, Life Skills, Counselling on ASRH, Menstrual Hygiene Management, SISo Nepal has set the priority areas of work on the following issues:

• Advocacy: Comprehensive Sexuality Education, ASRH and FP Information and Services
• Strategy, Policy and Guideline: Technical Support to GoN in developing strategies, policies & guidelines
• Research on Health Issues
• Training Toolkit/Packages/Manuals/Curriculum Development: Basic, Refresher, M/ToT
• Capacity Building of Teachers, Health Care Providers and Young Peoples on ASRH and Comprehensive Sexuality Education
• Establishment and Management of Adolescent Friendly Information Corners (AFIC): Demand Generation for FP and ASRH Services
• Trainings: Teachers, Health Care Providers and Adolescent/Young Peoples and Parents 
• IEC/SBCC including Materials Development Dissemination on CSE/ASRH and FP
• Counselling incl. Telephone Hotline Counselling
• Democracy, Peace and Human Rights
• Education Development